Currently I am trying to understand the role of copper in host-parasite interaction using the well-established macrophage-
Leishmania system.
Despite of the hostile microenvironment
, Leishmania is known to thrive inside the phagosomes of macrophages. Copper, being a potent antimicrobial agent, has been effective against several intracellular pathogens.
The study is aimed at revealing whether
Leishmania faces copper stress during infection and if so, how do they evade such stress.
Role of copper regulators present on both host and pathogen during infection is being studied including characterization of a novel copper transporter in the pathogen (Paul et al., JBC 2021).(https://pubmed.ncbi.nlm.nih.gov/34958799/)